The evaluation of sepsis by new endotoxin detection methods

新的内毒素检测方法评价脓毒症

• 批准号: 23591863
• 负责人: SHIMIZU Tomoharu
• 金额: $ 3.16万
• 依托单位: Shiga University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591863/
• 关键词: エンドトキシン; 敗血症性ショック; 敗血症; 高感度測定; Sepsis; Spetic shock; ショック; Septic shock; PMX

Endotoxin Laser Scattering Photometry (ESP) method may more sensitively detect endotoxins than the ordinary turbidimetric method. ESP significantly discriminated between patients with or without septic shock and sepsis compared to the ordinary method. There was no significant difference in predictive power between ESP and procalcitonin test that is one of common tools for the diagnosis of bacterial infection. The patients clinical conditions of septic shock due to intra-abdominal infection were improved by endotoxin adsorption therapy (PMX), reducing plasma endotoxins measured by ESP method. We also observed the reduction in the endotoxin after passing through column by ESP method even after the longer duration of PMX.

内毒素激光散射光度法（ESP）检测内毒素的灵敏度高于普通比浊法。与普通方法相比，ESP显著区分有或无感染性休克和脓毒症的患者。ESP和降钙素原试验之间的预测能力没有显着差异，降钙素原试验是诊断细菌感染的常用工具之一。内毒素吸附治疗（PMX）可降低ESP法测定的血浆内毒素水平，改善腹腔感染脓毒性休克患者的临床症状。我们还观察到通过ESP方法通过柱后内毒素的减少，即使在PMX的较长持续时间后。