The evaluation of sepsis by new endotoxin detection methods

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Endotoxin Laser Scattering Photometry (ESP) method may more sensitively detect endotoxins than the ordinary turbidimetric method. ESP significantly discriminated between patients with or without septic shock and sepsis compared to the ordinary method. There was no significant difference in predictive power between ESP and procalcitonin test that is one of common tools for the diagnosis of bacterial infection. The patients clinical conditions of septic shock due to intra-abdominal infection were improved by endotoxin adsorption therapy (PMX), reducing plasma endotoxins measured by ESP method. We also observed the reduction in the endotoxin after passing through column by ESP method even after the longer duration of PMX.