Regulation of Nuclear Receptor Functions

核受体是配体诱导的转录因子，调节多种生物现象，如细胞分化和增殖、代谢和动态平衡。核受体被认为是开发治疗癌症、心血管疾病、自身免疫性疾病和神经退行性疾病药物的重要分子靶点。在这项研究中，我开发了一些具有独特结构和生物功能的核受体的新型配体。

Nuclear receptors are ligand-inducible transcription factors, and regulate various biological phenomena, such as cell differentiation and proliferation, metabolism, and homeostasis. Nuclear receptors have been regarded as significant molecular targets for development of drugs for cancers, cardiovascular diseases, autoimmune diseases, and neurodegenerating diseases. In this study, I developed novel ligands for some nuclear receptors that have unique structures and biological functions.