A Study on Intranasal Transportation Dynamics of Medicinal Aerosol

雾化器治疗已被用于一些鼻部疾病。迄今为止，雾化器治疗的有效性已从临床观点得到证实。然而，从理论上和定量上评价雾化治疗效果的研究还很少。本研究应用计算流体力学（CFD）分析了五例患者的鼻内转运现象。本研究建立了鼻腔的三维几何模型。从结果来看，气流和药物液滴输送的特性强烈地依赖于流入条件，例如流入角、速度和颗粒尺寸，即使患者鼻腔形状存在个体差异。在较低的进口角和进口速度条件下，发现环流。这种循环流动可以延长气流和药物液滴在鼻腔中的停留时间，从而提高雾化治疗的效果。

Nebulizer treatment has been used for some nasal diseases. The effectiveness of the nebulizer treatment has been confirmed from clinical view points until now. However there are a few researches that evaluate the effect of the nebulizer treatment theoretically and quantitatively. This study analyzed intranasal transport phenomena for five patient's cases by means of Computational Fluid Dynamics (CFD). This study constructed three-dimensional geometry model of nasal cavities. From the results characteristics of airflow and medicinal droplet transportation strongly depend on inflow conditions such as inflow angle, velocity and size of particle even if there are the individual differences for the shape of patient's nasal cavity. Circulation flow is found in the lower inlet angle and inlet velocity conditions. This circulation flow is able to extend residence times of airflow and medicinal droplet in nasal cavity, consequently enhance the effect of the nebulizer treatment.