Identification of a novel nutrient signal related on health and longevity : role in the prevention of common diseases.

营养素及其代谢产物在维持正常生理功能所需的适当水平内保持平衡。不良饮食对营养代谢平衡的破坏会导致糖尿病、心血管疾病等生活方式相关疾病。在本研究中，我们研究了营养信号的作用，尤其是与衰老密切相关的“磷信号”和一些生活方式相关的疾病。高磷摄入引起的高磷血症可通过磷酸盐信号导致内皮功能障碍，是心血管疾病的危险因素。

Nutrients and their metabolites are balanced within adequate levels to maintain normal physiological functions. Impairment of the balance of nutrient metabolism by unfavorable diet causes life-style related diseases such as diabetes, cardiovascular disease, etc. In this research, we investigated the role of nutrient signal, especially focused on "phosphate signal" that is closely related on aging and some life-style related diseases. Hyperphosphatemia caused by high phosphate intake can induce endothelial dysfunction through the phosphate signal, and it would be a risk factor for cardiovascular cliseaSe.