Development of rat resources for human models of type 2 diabetes accompanied with obesity.

我们在肥胖的2型糖尿病大鼠OLETF中发现了一个与糖尿病发病有关的单一基因基因渗入的Nidd4或Nidd6位点。我们选择F344大鼠作为本底菌株。我们发现，这两种单基因菌株的体重、腹部脂肪量和空腹血糖均显著增加。根据这些结果，我们得出结论，糖尿病基因伴随肥胖存在于Nidd4和Nidd6位点区域。

We developed a single congenic rat introgressed Nidd4 or Nidd6 locus responsible for the onset of diabetes in obese type 2 diabetes rat, OLETF. We chose F344 rat as the background strain. We found that both single congenic strains showed significantly higher body weight, abdominal fat volume and fasting glucose, respectively. From these results, we conclude that a diabetes gene(s) accompanied with obesity exists in the region for Nidd4 and Nidd6 loci.