Construction of the standard chiroptical analysis method by vibrational circular dichroism

甘油脂是维持我们生命所必需的物质。虽然像大多数氨基酸一样，它们的手性碳数只有1，但它们的立体化学性质并不容易确定。为了建立一种确定其绝对构型的新分析方法，采用化学合成法制备了光学纯的甘油脂及其相关化合物，并对其进行了“振动圆二色”测定。通过对光谱数据的精确分析，首次发现了二酰基甘油脂（包括糖脂）立体化学的经验规律。

Glycerolipids are essential substances for sustaining our life. Although the number of their chiral carbon is only one like most of amino acids, their stereochemistry has not been assigned with ease. In order to establish a new analytical method for determination of their absolute configurations, optically pure glycerolipids and related compounds were prepared by chemical synthesis, and subjected to the "Vibrational Circular Dichromism" measurement. The precise analysis of their spectral data resulted in a discovery of an empirical rule on the stereochemistry of diacylglycerolipids including glycolipids for the first time.