Studies on Molecular Science of Biologically Active Natural Products Based on Chemical Synthesis

为促进具有生物活性的天然产物（生物体的次级代谢产物）三萜聚醚和生物碱的分子科学研究，开展了它们的化学合成。结果表明，我们成功地通过不对称全合成确定了omezakianol的完整立体结构，发展了isodehydrothyrsiferol的化学合成方法，并化学重现了teurilene和ekeberin D_4的仿生氧杂环化反应。此外，我们还成功地合成了houamine B的茚并四氢吡啶骨架。

To advance studies on molecular science of triterpene polyethers and alkaloids, biologically active natural products(secondary metabolites from organisms), their chemical syntheses were carried out. As a result, we have succeeded in determining the entire stereostructure of omaezakianol by the asymmetric total synthesis, developing the chemical synthesis method of isodehydrothyrsiferol, and chemically reproducing biomimetic oxacyclizations of teurilene and ekeberin D_4.In addition, an efficient synthesis of the indeno-tetrahydropyridine skeleton of houamine B has also been accomplished.