PROTEIN WORLD STUDIED BY PROTEIN DISTRIBUTION IN FAMILIES

利用高性能膜蛋白预测器分析了许多生物基因组的所有氨基酸序列，研究了蛋白质世界概念的有效性。通过对包含跨膜区外显子分布的分析，得出外显子洗牌现象在真核生物基因组中广泛存在的结论。分析了原核生物真实基因组和模拟基因组的膜蛋白跨膜区数量分布。结果表明，单指数分布是由于跨膜数变化的平衡所致。真核生物和原核生物的结果表明，膜蛋白家族在基因组中已经达到了随机过程的平衡。

The validity of the concept of protein world was investigated by analyzing all amino acid sequences from the total genomes of many organisms, using a high performance membrane protein predictor. The analyses of the distribution of exons containing membrane spanning regions lead to the conclusion that the exon shuffling extensively occurred in eukaryotic genomes. The number distribution of transmembrane regions in membrane proteins was analyzed for real genomes and simulated genomes of prokaryotic genomes. The result indicated that the single exponential distribution is due to the equilibrium of the change in the transmembrane numbers. The results for both eukaryotes and prokaryotes suggested that the families of membrane proteins have already reached to the equilibrium of random processes in genomes.