Research and development of bioactive marine natural products

冲绳一种海洋生物(海绵、被膜和甲藻等)提取物的研究结果分离出具有抗疟疾和抗锥虫活性的新的山竹碱类生物碱，具有乙酰胆碱酯酶抑制活性的新的吡啶生物碱和具有酪氨酸激酶抑制活性的新的萜类化合物。此外，从海洋生物中分离到许多具有细胞毒活性的新化合物(吡啶生物碱、β-咔啉生物碱、溴酪氨酸生物碱、大环内酯和倍半萜)和抗微生物活性(溴吡咯生物碱、溴酪氨酸生物碱、三萜类)。已知的细胞毒性大环内酯类化合物的绝对立体化学也被阐明，这些大环内酯类化合物是我们以前从甲藻中分离出来的。

Investigation of extracts of an Okinawan marine organisms (sponge, tunicate, and dinoflagellate etc.) resulted in the isolation of new manzamine alkaloids exhibiting antimalarial and antitrypanosomal activities, new pyridinium alkaloids exhibiting acetylcholine esterase inhibitory activity, and new terpenoid quinones exhibiting tyrosine kinase inhibitory activity. In addition, many new compounds that show cytotoxic activity (pyridine alkaloids, beta-carboline alkaloids, bromotyrosine alkaloids, a macrolide, and sesquiterpenoids) and anti-microbial activity (bromopyrrole alkaloids, bromotyrosine alkaloids, triterpenoids) were isolated from the marine organisms. The absolute stereochemistries of known cytotoxic macrolides, previously isolated from dinoflagellete by our group, were also elucidated.