The relation between CYP19 haplotypes and breast cancer risk in Japanese women

近年来，日本乳腺癌的发病率和死亡率显著上升，尤其是在绝经后的女性中。许多可能与癌症发生相关的酶的基因多态性已经被检测为乳腺癌的风险。芳香酶是雌激素生物合成的关键酶之一，由CYP19A1编码。为了评估CYP19A1单倍型对乳腺癌风险的影响，我们进行了一项病例对照研究。CYP19A1中的某些单倍型可能会影响性激素水平，因此提示CYP19A1单倍型对乳腺癌风险具有潜在的重要性。

Incidence and death rates of breast cancer in Japan have increased markedly in recently years, especially among postmenopausal women. Many gene polymorphisms of enzymes potentially related to carcinogenesis have been examined for breast cancer risk. Aromatase is one of the key enzymes in estrogen biosynthesis and encoded by CYP19A1. To evaluate impact of CYP19A1 haplotypes on breast cancer risk, we conducted a case-control study. Some haplotyeps in CYP19A1 would influence sex hormones levels, thus suggesting potential importance of CYP19A1 haplotypes on breast cancer risk.