CYP19(aromatase) haplotypes and breast cancer risk among Japanese women

日本女性的 CYP19（芳香酶）单倍型与乳腺癌风险

• 批准号: 18590582
• 负责人: HIROSE Kaoru
• 金额: $ 2.49万
• 依托单位: Aichi Prefectural Institute of Public Health
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590582/
• 关键词: breast cancer; haplotype; estsorgen

The CYP19 gene encodes for aromatase(P450arom) , a key steroidogenic enzyme that catalyzes the final step of estrogen biosynthesis. Apart from rare mutations in CYP19 which result in severe phenotypes associated with estrogen insufficiency, little is known about whether common variation in CYP19 is associated with risk of hormone-related diseases. In this study, we employed a haplotype-based approach to survey common genetic variation across CYP19 gene in relation to circulating postmenopausal steroid levels. Twenty-five haplotype-tagging SNPs were selected from the HapMap database and genotyped using Taqman[○!R] in a study set of Japanese women without any cancers. We determined 7 haplotype blocks(block 1 - block 7) and further investigated the association between haplotype and serum level of estsrone(E1) , estradiol(E2) , testosterone(T) , sex hormone binding globlin(SHBG) , respectively. Block 1 is related to circulating levels of E1 and block 7 is associated with a difference in circulating level of T. These finding suggested that genetic variation in CYP19 gene produces measurable differences in estrogen levels among postmenopausal Japanese women and may contribute to breast cancer risk.

CYP 19基因编码芳香酶（P450 arom），一种催化雌激素生物合成最后一步的关键类固醇生成酶。除了导致与雌激素不足相关的严重表型的CYP 19中的罕见突变外，关于CYP 19中的常见变异是否与雌激素相关疾病的风险相关知之甚少。在这项研究中，我们采用了单倍型为基础的方法来调查跨CYP 19基因的常见遗传变异与循环绝经后类固醇水平。从HapMap数据库中选择25个单倍型标记SNP，并使用Taqman[○！在一组没有任何癌症的日本女性中进行研究。我们确定了7个单倍型区组（区组1 -区组7），并进一步研究了单倍型与血清雌激素（E1）、雌二醇（E2）、睾酮（T）、性激素结合球蛋白（SHBG）水平的关系。阻断1与E1的循环水平有关，阻断7与T的循环水平的差异有关。这些发现表明，CYP 19基因的遗传变异在绝经后的日本妇女中产生了可测量的雌激素水平差异，并可能导致乳腺癌的风险。

项目成果

Dietary factors and breast cancer.

饮食因素与乳腺癌。

• 发表时间: 1986
• 期刊: Cancer Surveys
• 作者: D. Rose

Risk of colorectal cancer is linked to erythrocyte compositions of fatty acids as bromarkers for dietary intakes of fish, fat, and fatty acids

结直肠癌的风险与红细胞脂肪酸组成有关，脂肪酸是饮食中鱼、脂肪和脂肪酸摄入量的溴标记物

• 发表时间: 2006
• 期刊: Cancer Epidemiol Biomarkers Prev 15
• 作者: Kuriki K.;et. al.
• 通讯作者: et. al.

Dietary patterns and the risk of breast cancer in Japanese women

• DOI: 10.1111/j.1349-7006.2007.00540.x
• 发表时间: 2007-09-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Hirose, Kaoru;Matsuo, Keitaro;Tajima, Kazuo
• 通讯作者: Tajima, Kazuo

Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARγ gene and colorectal cancer risk in Japanese

• DOI: 10.1111/j.1349-7006.2006.00314.x
• 发表时间: 2006-11-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Kuriki, Kiyonori;Hirose, Kaoru;Tajima, Kazuo
• 通讯作者: Tajima, Kazuo

Risk of colorectal cancer is linked to erythrocyte compositions of fatty acids as biomarkers for dietary intakes of fish, fat, and fatty acids

• DOI: 10.1158/1055-9965.epi-06-0180
• 发表时间: 2006-10-01
• 期刊: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
• 影响因子: 3.8
• 作者: Kuriki, Kiyonori;Wakai, Kenji;Tajima, Kazuo
• 通讯作者: Tajima, Kazuo