Search and the functional analysis of lipophilic signaling molecule as a regulator of adipogenesis in the ruminants.

迄今为止，反刍动物脂肪形成的调控机制尚不清楚。因此，本研究对反刍动物脂肪形成的亲脂性信号分子进行了筛选和功能分析。本研究证明VFA和lactoseureid分别是控制反刍动物PPAR γ-2和LXRα基因表达的内源性和外源性因子，VFA是反刍动物脂肪细胞分化的诱导剂和调节剂。

To date, the regulating mechanism of adipogenesis in the ruminants have not been clear. Therefore, we investigated the search and the functional analysis of lipophilic signaling molecule as a regulator of adipogenesis in the ruminants. In this study we demonstrated that VFA and lactoseureid are an intrinsic and an extrinsic factor, respectively, controlling the gene expression of PPAR γ-2 and LXRα in the ruminants, and VFA is a prominannt inducer and regulator on the ruminant adipocyte differentiation.