Pathophysiological roles of signal transductions between cholinergic nerves, interstitial cells and smooth muscle cells in overactive bladder.

在本研究中，我们试图阐明膀胱过度活动的发生机制，并研究膀胱过度活动模型小鼠膀胱平滑肌对电场刺激内源性神经的收缩反应。结果表明，在模型小鼠中，负责未知神经刺激的膀胱收缩成分增加，这种未知成分可能是治疗膀胱过度活动的新药的有用靶点。

In the present study, we attempted to clarify the phathogenetical mechanisms for the development of overactive bladder and investigated contractile responses of bladder smooth muscles to electrical field stimulation of intrinsic nerves in model mouse of overactive bladder. The results suggest that a component of bladder contraction responsible for unknown nerve stimulation was increased in the model mouse and that this unknown component may be a useful target for the new drugs for the treatment of overactive bladder.