Prediction of host specificity of morbillivirus based on the analysis of receptor in marine mammals

信号淋巴细胞活化分子（SLAM）是麻疹病毒的主要细胞受体。测定了鳍足类和海牛类5种鲸类SLAM cDNA的全序列，并建立了三维模型。我们在SLAMs的V结构域上发现了一些氨基酸残基，这些氨基酸残基可能会影响SLAMs与病毒蛋白的结合和宿主病毒的特异性。在13个氨基酸残基位置上发现了鲸类物种间的差异。第68、82、90、130位残基位置的改变被认为影响了与病毒的结合。

Signaling lymphocyte activation molecule (SLAM) is a major cellular receptor for morbilliviruses. The complete nucleotide sequences of SLAM cDNA from five species of cetacean, pinniped and sirenian, were determined and the three-dimensional models were generated. We found some amino acid residues on the V domains of the SLAMs, which possibly affect the binding with the viral protein and host-virus specificity. The variation among cetacean species was found at 13 amino acid residue positions. The change of residues position at 68, 82, 90, and 130, were thought to affect the binding with virus.