Analysis for carcinogenesis of lung cancer in idiopathic pulmonary fibrosis by inflammation and precancerous change

特发性肺纤维化是一种原因不明的难治性间质性肺炎，是肺癌的高危因素。为了研究鳞状细胞癌伴或不伴特发性肺纤维化的差异，比较每个鳞状细胞癌样本的转录组表达水平。已知癌基因MYCN、细胞骨架蛋白MYH 11、未知功能蛋白ARMC 4表达上调。其中一个下调的蛋白是MTSS-1，它可能起着分解肌动蛋白纤维的作用。

Idiopathic pulmonary fibrosis is the interstitial pneumonia of unknown cause and refractory lesion, with a high risk for lung cancer. To study the difference of squamous cell carcinoma with or without idiopathic pulmonary fibrosis, the transcriptome expression level of each squamous cell carcinoma sample were compared. Famous oncogene MYCN, cytoskeleton protein MYH11, unknown function protein ARMC4 were upregulated. One of downregulated protein was MTSS-1 which supposed to be the role as disassembling the actin fibers.