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The mechanisms of sexual reproduction of malaria parasites

The mechanisms of sexual reproduction of malaria parasites
疟疾寄生虫的有性繁殖机制
批准号:
20590426
负责人:
HIRAI Makoto
金额:
$2.25万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

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相关文献

中文摘要
翻译
通过比较基因组学分析,我们确定了疟疾中植物繁殖因子的同源基因GCS1(生殖细胞特异性1),并将其命名为PbGCS1。PbGCS1(-)寄生虫完全失去了育性,表明PbGCS1确实是植物GCS1的功能同源基因。我们的发现表明,基于GCS1的有性生殖系统在各种生物体中都是保守的。
英文摘要
By performing comparative genomics analysis, we identified the malaria orthologue of plant reproduction factor, GCS1 (Generative Cell Specific 1) and named it as PbGCS1. PbGCS1(-) parasites completely lost the fertility, indicating that PbGCS1 is surely functional orthologue of plant GCS1. Our findings indicate that GCS1-based sexual reproduction systems are conserved in various organisms.
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会议论文
Male fertility of malaria parasite is determined by GCS, a plant-typereproduction factor
疟疾寄生虫的雄性生育能力由 GCS(一种植物型繁殖因子)决定
DOI: --
发表时间: 2008
期刊: Current Biology 18
影响因子: --
作者: [Chang H, Yoshimoto M, Umeda K, Iwasa T, Mizuno Y, Fukada SI, Yamamoto H, Motohashi N, Miyagoe-Suzuki Y, Takeda S, Heike T, Nakahata T, 宮田健, 平井誠]
通讯作者: 平井誠
DOI: 10.1128/jcm.00331-10
发表时间: 2010-07-01
期刊: JOURNAL OF CLINICAL MICROBIOLOGY
影响因子: 9.4
作者: [Iseki, Hiroshi, Kawai, Satoru, Igarashi, Ikuo]
通讯作者: Igarashi, Ikuo
DOI: 10.1016/j.cub.2008.03.045
发表时间: 2008-04-22
期刊: CURRENT BIOLOGY
影响因子: 9.2
作者: [Hirai, Makoto, Arai, Meiji, Matsuoka, Hiroyuki]
通讯作者: Matsuoka, Hiroyuki
The Plasmodium HU homolog, which binds the plastid DNA sequence-independently, is essential for the parasite's survival
疟原虫 HU 同源物独立地结合质体 DNA 序列,对于寄生虫的生存至关重要
DOI: --
发表时间: 2009
期刊: FEBS Letters 583
影响因子: --
作者: [Sasaki N, Hirai M, et al]
通讯作者: et al
共 23 条
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