Research on host factors involved in early steps of HIV-1 replication

我们分析了宿主因子在早期的HIV-1复制步骤中加入，并在旧世界猴细胞中发现了一种受抑制的HIV-1复制的环素。我们还发现了TRIM 5的逆转录病毒限制机制，该机制依赖于主机和病毒的组合。Furthermore，我们在猴子区域发现了SIVmac胶囊蛋白是必要的，可以完全从rhesus monkeym TRIM 5.限制。

We analyzed host factors involved in early steps of HIV-1 replication and found that cyclophilin A suppressed HIV-1 replication in Old World Monkey cells. We also found that the mechanisms of retrovirus restriction by TRIM5・ vary depending on the combination of host and virus. Furthermore, we found that monkey regions of the SIVmac capsid protein are necessary for complete evasion from rhesus monkeym TRIM5・ restriction.