Is there some acetaldehyde formation in the brain?

对高乙醛（乙醇代谢物）形成模型（HAF）大鼠和醛脱氢酶2敲除（ALDH2-KO）小鼠给予乙醇后，得到以下结果：1. 在HAF大鼠和ALDH2-KO小鼠中均检测到高乙醛（AcH）水平，2。脑乙酰胆碱含量为血液的1/5 -1/8。过氧化氢酶抑制剂（叠氮化钠或3-氨基-1,2,4-三唑）预处理的HAF大鼠和ALDH2-KO小鼠脑乙酰胆碱（AcH）水平低于未预处理的小鼠和4。乙酰胆碱能降低ALDH2-KO小鼠脑胆碱能标记物mRNA表达。这些结果表明，乙酰胆碱酶是通过过氧化氢酶活性在体内脑内形成乙酰胆碱的，并且对脑胆碱能神经神经元有影响。

After ethanol dosing to high acetaldehyde (ethanol metabolite) formation model (HAF) rats and aldehyde dehydrogenase 2 knockout (ALDH2-KO) mice, following results were obtained. 1. High acetaldehyde (AcH) levels were detected in the both HAF rats and ALDH2-KO mice, 2. the brain AcH levels were 1/5th-1/8th of the blood, 3. brain AcH levels of the HAF rats and ALDH2-KO mice pretreated with catalase inhibitors (sodium azide or 3-amini-1,2,4-triazole) were lower than those without pretreatment and 4. AcH reduced the mRNA expression of brain cholinergic markers in ALDH2-KO mice. These results suggested that AcH formation are performed in vivo brain through catalase activity and brain AcH has effects on brain cholinergic nerve neurons.