Molecular basis of hyperthermia-thorough investigation into a newly identified heat-shock induced protein

FAM107家族（Family with sequence similarity 107, FAM107）在哺乳动物中由FAM107A和fam107b两个亚型组成。关于FAM107A作为候选肿瘤抑制基因的新数据已经积累，尽管关于FAM107家族的另一个蛋白FAM107B的生物学信息很少。我们报道了FAM107B在癌症和热休克刺激下表达下调，并将其命名为热休克诱导的肿瘤小蛋白（HITS）。由于强迫表达HITS抑制肿瘤生长，因此HITS可能是一种潜在的肿瘤抑制基因，这与先前描述的其他热休克蛋白的致癌活性形成对比。

Family with sequence similarity 107 (FAM107) consists of two subtypes of FAM107A and B in mammals. Emerging data regarding FAM107A as a candidate tumor suppressor gene have been accumulated, although few biological information is available about the other FAM107 family protein, FAM107B. We have reported that FAM107B expression was downregulated in cancer and induced by heat-shock stimulation, and designated it as heat shock-inducible tumor small protein (HITS). Since forced expression of HITS inhibited tumor growth, HITS would be a potential tumor suppressor gene, which contrasts with previously described oncogenic activities of other heat shock proteins.