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Prevention of diabetic nephropathy by MafB

Prevention of diabetic nephropathy by MafB
MafB 预防糖尿病肾病
批准号:
20590944
负责人:
MORITO Naoki
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
We have investigated the function of MafB in glomerular epithelial cells. By database surveillance, we have found Maf recognition element (MARE) in the regulatory region of nephrin and podocin gene. Gel mobility shift assays identified that MafB binds to the MARE of the nephrin and podocin gene. Reporter assay also showed MafB could activate the nephrin gene transcription through the MARE. The expression of MafB was decreased in murine diabetic nephropathy models, as well as the expression of nephrin. Diabetic nephropathy might be prevented by overexpression of MafB in glomerular epithelial cells.
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会议论文
NEW MURINEMODEL OF RENAL INVOLVEMENT IN MULTIPLE MYELOMA, Eμ C-MAF TRANSGENIC MICE.
多发性骨髓瘤肾脏受累的新小鼠模型,Eμ C-MAF 转基因小鼠。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Morito N, et al.]
通讯作者: et al.
DOI: 10.1158/0008-5472.can-10-1057
发表时间: 2011-01-15
期刊: CANCER RESEARCH
影响因子: 11.2
作者: [Morito, Naoki, Yoh, Keigyou, Takahashi, Satoru]
通讯作者: Takahashi, Satoru
DOI: 10.1007/s10157-008-0120-z
发表时间: 2009
期刊: Clinical and Experimental Nephrology
影响因子: 2.3
作者: [K. Sakai, J. Usui, H. Kai, M. Hagiwara, Naoki Morito, Chie Saito, K. Yoh, Syuichi Tsuruoka, K. Hirayama, K. Aita, Michio Nagata, K. Yamagata]
通讯作者: K. Yamagata
Overexpression of T-bet in T cells accelerates autoimmune glomerulonephritis in mice with a dominant Th1 background.
T 细胞中 T-bet 的过度表达会加速 Th1 背景显性小鼠的自身免疫性肾小球肾炎。
DOI: --
发表时间: 2009
期刊: J Nephrol. 22
影响因子: --
作者: [Shimohata H, Yamada A, Yoh K, Ishizaki K, Morito N, Yamagata K, Takahashi S]
通讯作者: Takahashi S
11
    The role of Mafb in secondary hyperparathyroidism.
    • 批准号:
      24591223
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2012
    • 负责人:
      MORITO Naoki
    • 依托单位: