Regulatory role of nucleo-cytoplasmic transport in microtubule network organization

在分裂酵母细胞以及几乎所有真核细胞中，微管结构的动态重排发生在细胞周期转变过程中。我提出核胞质转运在时空调节的微管网络组织中起核心作用。在该模型中，微管蛋白和微管蛋白相关蛋白在间期积极向核外输出，“间期微管组织中心”促进细胞质微管的形成，而它们进入细胞核，有丝分裂纺锤体的形成则由有丝分裂激活的纺锤体极体促进。

In fission yeast cells as well as almost all eukaryotic cells, dynamic rearrangement of microtubule structure occurs at the cell cycle transition. I proposed that nucleo-cytoplasmic transport plays a central role in spatio-temporally regulated microtubule network organization. In this model, tubulin and tubulin-associated proteins are actively exported toward outside of the nucleus during interphase, and cytoplasmic microtubule formation is promoted by 'interphase microtubule organizing center', while they imported into the nucleus and mitotic spindle formation is promoted by mitotically activated spindle pole bodies.