Investigation of the drug-CYP3A4 interaction by the use of high resolution structure analysis

CYP3A4是负责药物代谢的关键酶。研究酶的构效关系对新药设计具有重要意义。然而，很难获得足够量的重组CYP3A4作为可溶性蛋白。因此，CYP3A4的制备仍然是一个重要的问题。

CYP3A4 is a key enzyme responsible for drug metabolism. The study in structure-function relationship of the enzyme is important with respect to design for new drug. However, it is difficult to obtain enough amount of recombinant CYP3A4 as a soluble protein. Thus, the preparation of CYP3A4 remains an important problem.