Study for biological function in prostate cancer of SND1 and its role for therapeutic target.

本研究的目的是阐明SND1在前列腺癌中的生物学功能。制备了前列腺特异表达SND1的转基因小鼠，并对前列腺进行了组织学观察。在18个月大的时候，没有观察到前列腺癌。提取前列腺组织总RNA，进行基因芯片，观察SND1基因表达的变化。比较转基因小鼠和对照组小鼠基因表达的变化，并用实时荧光定量聚合酶链式反应证实这种变化。一些分子被发现并被认为在前列腺癌的发生中起到了作用。

The aim of the study was to elucidate the biological function of SND1 in prostate cancer. Transgenic mouse expressed SND1 prostate-specifically was produced and the prostate was observed histologically. At the 18 months old, cancer was not observed in the prostate. To observe the molecular change according to SND1 expression, microarray was performed using total RNA extracted from the prostate. Change of expression was compared between TG and control mice and the change was confirmed by real time PCR. Some molecules were identified and thought to have roles in carcinogenesis of prostate cancer.