Neuroimaging study to predict clinical response of obsessive-compulsive disorder by using 3-Tesla proton MRS and multichannel NIRS
Neuroimaging study to predict clinical response of obsessive-compulsive disorder by using 3-Tesla proton MRS and multichannel NIRS
批准号:
20591410
负责人:
SUMITANI Satsuki
金额:
$3.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
应用3-特斯拉质子磁共振波谱(MRS)和多道近红外光谱(NIRS)对强迫症的临床反应进行预测。在使用非典型抗精神病药物的SSRI应答者中,观察到自知力水平显著降低,起病时间更早。3-TESLA质子磁共振波谱显示强迫症患者右侧基底节区NAA/Cr高于对照组,多道近红外光谱显示强迫症患者右侧基底节NAA/Cr值高于对照组。
英文摘要
We studied to find predictors of clinical response of obsessive-compulsive disorder by using 3-Tesla proton magnetic resonance spectroscopy(MRS) and multichannel near-infrared spectroscopy(NIRS). Significantly lower insight levels and earlier onset were observed in responders to SSRI with atypical antipsychotic. Obsessive-compulsive disorder patients showed higher level of NAA/ Cr in right basal ganglia by using 3-Tesla proton MRS and hypofrontality by using multichannel NIRS compared to control group.
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DOI:
10.1007/s10803-010-1065-0
发表时间:
2011-04-01
期刊:
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
影响因子:
3.9
作者:
[Harada, Masafumi, Taki, Masako M., Matsuda, Tsuyoshi]
通讯作者:
Matsuda, Tsuyoshi
DOI:
10.1002/ajmg.b.30852
发表时间:
2009-06-05
期刊:
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
影响因子:
2.8
作者:
[Numata, Shusuke, Iga, Jun-ichi, Ohmori, Tetsuro]
通讯作者:
Ohmori, Tetsuro
多チャンネルNIRSを用いた表情刺激に対する快不快判断と性別判断の前頭葉血流変化の比較
使用多通道 NIRS 比较额叶血流变化对面部刺激的愉快和不愉快判断以及性别判断
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Medalia A, et al. 著(中込和幸ら監訳), 飯塚優子]
通讯作者:
飯塚優子
Measurement of Variation in the Human Cerebral GABA Level by in vivo MEGA-Editing Proton MR Spectroscopy using a Clinical 3 Tesla Instrument and its Dependence on Brain Region and the Female Menstrual Cycle
使用临床 3 特斯拉仪器通过体内 MEGA 编辑质子 MR 光谱测量人类大脑 GABA 水平的变化及其对大脑区域和女性月经周期的依赖性
DOI:
--
发表时间:
2011
期刊:
Human Brain Mapping
影响因子:
4.8
作者:
[Harada M, Kubo H, Nose A, Nishitani H, Matsuda T]
通讯作者:
Matsuda T
強迫性障害の現在とこれからOCDの病態:神経化学的側面を中心に
强迫症的现状和强迫症的未来病理学:关注神经化学方面
DOI:
--
发表时间:
2009
期刊:
精神神経学雑誌
影响因子:
--
作者:
[Tagami S., Okochi M., Fukumori A., Jingwei J., Yanagida K., Nakayama T., Morihara T., Tanaka T., Kudo T., Takeda M., Canuet L et al, 池澤聰, 住谷さつき, 最上多美子, 住谷さつき]
通讯作者:
住谷さつき
共 38 条
An intermediate phenotype study of clinical responses of obsessive-compulsive disorder by using high resolution MRS and NIRS
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批准号:26461720
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2014
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负责人:SUMITANI Satsuki
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依托单位:
A study of treatment strategies for obsessive-compulsive disorder by using cognitive performance and functional neuroimagings
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批准号:23591709
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2011
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负责人:SUMITANI Satsuki
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依托单位:
The study of amino acid neurotransmitter changes in mood disorder and anxiety disorder assessed by high field proton MRS.
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批准号:18591291
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.49万
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财政年份:2006
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负责人:SUMITANI Satsuki
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依托单位: