CHANGE OF BRAIN FUNCTION ALONG WITH TREATMENT EFFECT IN PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDRDER ; AN FUNCTIONAL MRI STUDY

我们研究了强迫症患者的大脑变化的差异与BT，氟伏沙明（FLV），并使用Stroop测试评估抑制过程，可能与强迫症症状的控制治疗。结果，在比较FLV组和对照组的分析中，仅检测到右背外侧前额叶皮层（DLPFC）。BT组与对照组相比，左侧（非右侧）以及颞顶区的其他几个区域在分析中也显示出显著性差异。DLPFC被认为是与OCD的病理生理学相关的区域之一，特别是在执行功能的计划方面。

We investigated the differences of brain change among OCD patients treated with BT, fluvoxamine (FLV), and control treatment using Stroop test assessing inhibition processes that might be related with OCD symptoms. As the result, only the right dorsolateral prefrontal cortex (DLPFC) was detected in analysis comparing the FLV group to the control group. The region( not right, but left), as well as other several ones in temporal and parietal area, showed significantly different change in analysis between the BT group and the control group, too. The DLPFC has been suggested as one of the regions related to the pathophysiology of OCD, especially in planning aspects of executive function.