The role of the adipocyte function in the gender-specific medicine after the surgical stress : the effectiveness of the pioglitazone administration

脂肪组织被认为是一个内分泌/免疫器官，分泌各种生物活性分子，概念为脂肪因子。然而，大手术后脂肪组织先天功能的性别相关改变机制尚不清楚。本研究旨在探讨性别差异对胃肠大手术患者先天炎症反应和脂肪组织功能的影响。男女患者在年龄、手术时间、出血量等方面无显著差异。然而，由于术后并发症，女性的发病率明显低于男性。男性患者术前脂联素和瘦素水平低于女性患者，术后脂联素和瘦素水平明确显示女性术后炎症反应较低。这些发现表明，男性患者在大手术后可能出现术后免疫抑制，而女性患者在术后早期具有免疫优势，包括脂肪功能。

Adipose tissue is considered to be an endocrine/immune organ secreting a variety of biologically active molecules, conceptualized as adipokines. However, the mechanism of gender-related alterations in the innate function of adipose tissue after major surgery is still unknown. The aim of this study was to investigate the effect of gender differences in innate inflammatory responses and the function of adipose tissue in patients undergoing major gastrointestinal gastrointestinal surgery. There were no significant differences in terms of age, operation time, or blood loss between male and female patients. However, the women had a significantly lower morbidity rate due to postoperative complication than did the men. Preoperative levels of adiponectin and leptin were lower in male patients than in female patients and postoperative adiponectin and leptin levels have clearly shown lower inflammatory responses in women after surgery. These findings suggest that male patients might develop postoperative immune suppression after major surgery, whereas female patients have an immunological advantage including adipose function during the early postoperative period.