Nutritional effects of the novel fat emulsion emulsified by phosphatidylglycerol after cirrhotic liver resection

我们建立了一种以磷脂酰甘油(PG)乳化的新型脂肪乳剂，并对硫代乙酰胺处理的大鼠肝硬变切除术后的营养管理效果进行了评价。PG乳剂不仅能抑制血清甘油三酯和游离脂肪酸的升高，而且还能抑制、快速输注后2小时血清磷脂水平的升高，甚至对肝硬变大鼠血清磷脂的升高也有抑制作用。因此，没有发生暂时性高脂血症。PG乳剂中的甘油三酯转移到肝细胞的速度比现有的磷脂酰胆碱乳化乳剂快得多。即使在肝切除合并肝硬变的大鼠中，PG乳剂也保持了较高的肝脏能量电荷水平。在电子显微镜下，PG乳剂被迅速带入肝细胞并被代谢。从这项研究的结果来看，一种新型的PG乳剂能迅速清除血流，快速转移到肝细胞，并在肝细胞中产生能量。因此，我们推测一种新的PG乳剂可能可用于不使用商业脂肪乳剂的肝硬变切除。

We established a novel fat emulsion emulsified by phosphatidylglycerol (PG) and evaluated the efficacy on nutritional management after cirrhotic liver resection in thioacetamide-treated rats. PG emulsion inhibited not only the increases in serum triglyceride and free fatty acids, but also inhibited increases in serum levels of phospholipids for 2 hours after rapid infusion、even in hepatectomized rats with liver cirrhosis. Thus, temporary hyperlipidemia did not occur. Triglycerides from PG emulsion transferred into the hepatic cells much more rapidly than existing emulsions emulsified by phosphatidylcholine. The infusion of PG emulsion maintained a high level of energy charge of the liver even in hepatectomized rats with liver cirrhosis. On the electron microscopic findings, PG emulsion was rapidly taken into the hepatic cells and metabolized. From the results of this study, a novel PG emulsion produced rapid clearance from the blood stream, rapid transfer into the hepatic cells, and efficacy in energy production in the hepatic cells. Thus, we speculated that a novel PG emulsion might be available for cirrhotic liver resection in which commercial fat emulsions are not used.