Identification of epigenetic biomarkers in benign brain tumors in the post-genome era

我们详尽分析了脑膜瘤（最常见的脑肿瘤）的表观遗传学变化。使用可以分析6157个基因组的微阵列，分析了15273个CpG岛，20个WHO 1级和10个2级脑膜瘤。数据显示2个聚类，低甲基化和高甲基化组，独立于WHO分级。大多数侵袭性脑膜瘤和复发性脑膜瘤被包括在高甲基化集群中。我们的结果表明，DNA甲基化的表观遗传变化反映了脑膜瘤的活动性质，例如侵袭或复发。

We analyzed exhaustive epigenetic changes of the meningioma, the most common brain tumor. Using microarrays that can analyze 6157 genomes, 15273 CpG islands, 20 WHO grade 1 and 10 grade 2 meningiomas were analyzed. The data showed 2 clusters, hypo-methylated and hyper-methylated groups, independent of WHO grading. Most invasive meningiomas and recurrent meningiomas were included in the hyper-methylated cluster. Our results suggest that epigenetic changes of DNA methylation reflect active nature, such as invasion or recurrence, of the meningiomas.