Targeted delivery of magnetic Iiposome encapsulated platelet rich plasma for bone formation in a rat bone-defect model

本研究的目的是在外加磁力的作用下，将富血小板血浆PRP磁性脂质体聚集到人工骨上，促进骨形成和骨诱导，以修复大鼠骨缺损。在大鼠股骨干中段造成临界尺寸的节段性骨缺损(5 Mm)。将多孔羟基磷灰石陶瓷植入骨缺损区，用1.2 mm克氏针固定。实验分为3组，分别为PRP组、PRP包埋组和外加磁力的PRP包埋组。在PRP组中，新骨形成在放射学和组织学上都比非PRP组得到很好的识别。

The purpose of this study is to reconstruct a large bone defect by collecting Platelet rich plasma PRP encapsulated magnetic liposomes to the artificial bone with use of the external magnetic force and promoting bone formation and bone induction.A critical sized segmental bone defect (5mm) was created in the mid-part of the femoral shaft in a rat. An interconnected porous hydroxyapatite ceramic was intercalated in the bone defect and fixed by a 1.2mm kirschner-wire. There were three treatment groups, PRP only, PRP encapsulated magnetic liposomes only, and PRP encapsulated magnetic liposomes with external magnetic force. In the PRP group, new bone formation was well recognized radiologically and histologically than the non-PRP group.