Treatment of infected wound with omentum-derived cells

肌瓣和网膜瓣用于治疗感染的伤口。根据我们的临床经验和以往的实验，我们认为网膜瓣比肌肉瓣对感染伤口更有效。然而，关于网膜瓣抗感染作用的报道很少。在建立了新的感染创面模型后，我们将大网膜皮瓣与肌肉皮瓣进行了比较。此外，我们还研究了大网膜来源细胞的抗感染作用。首先用半流体培养基加金黄色葡萄球菌建立稳定的新型感染创面模型。当我们在这个模型中比较大网膜皮瓣和肌肉皮瓣时，一些肌肉皮瓣对感染的伤口有反应。另一方面，大多数大网膜瓣对伤口有反应：大网膜瓣粘附周围组织并提供大量炎症细胞。当我们将大网膜来源的细胞注射到感染的伤口时，这些细胞局部存活并新生血管，并被大量炎症细胞包围。综上所述，这些发现表明网膜皮瓣比肌肉皮瓣更有效地治疗感染伤口。有一种可能是网膜来源的细胞对感染的伤口有抗感染的作用。

Muscle flaps and omental flaps are used for treatment of infected wound. We think omental flaps are more effective for infected wound than muscle flaps by our clinical experiences and previous experiments. However, there are few repots involving anti-infective effects of omental flaps. After we established a new infected wound model, we compared omental flaps to muscle flaps in this model. Furthermore, we investigated the anti-infective effects of omentum-derived cells. At first, we established a new stable infected wound model by the semi-fluid medium plus Staphylococcus aureus. When we compared omental flaps to muscle flaps in this model, a few muscle flaps responded to the infected wound. On the other hand, most omental flaps responded to the wound : omental flaps adhered the surrounding tissue and supplied a lot of inflammatory cells. When we injected the omentum-derived cells to the infected wound, these cells survived locally with neovascularization and were surrounded by a lot of inflammatory cells. Taken together, these findings indicate omental flaps are more effective for infected wound than muscle flap. There's a possibility that omentum-derived cells have the anti-infective effect for the infected wound.