Influence of Duodeno-Gastro-Esophageal Reflux on Sleep Bruxism

先前的研究表明，睡眠磨牙症（SB）与胃食管反流之间存在关联；然而，这种关系从来没有被描述过。为了研究食管内酸化是否会诱发SB，我们进行了一项随机试验，比较食管内灌注5ml酸性溶液（0.1 N HCl, pH 1.2）和灌注生理盐水后的咀嚼肌活动。对12例无SB的健康成年男性进行了咬肌肌电图（EMG）多导睡眠图、录音录像和食道pH监测。在酸性输注后的20分钟内，肌电图爆发频率、咀嚼肌节律性活动（RMMA）发作频率、磨声频率和RMMA/微觉醒比明显高于生理盐水输注后的20分钟。这些结果表明，包括SB在内的RMMA发作是由食管酸化引起的。

Previous studies have suggested an association between sleep bruxism (SB) and gastroesophageal reflux ; however, the relationship has never been characterized. To examine whether intra-esophageal acidification induces SB, we conducted a randomized trial to compare masticatory muscle activity after intraesophageal infusion with 5 ml acidic solution (0.1 N HCl, pH 1.2) and infusion with saline. Polysomnography with electromyogram (EMG) of the masseter muscle, audio-video recording, and pH monitoring of the esophagus were performed in 12 healthy adult males without SB. The frequencies of EMG bursts, rhythmic masticatory muscle activity (RMMA) episodes, grinding noise, and the RMMA/microarousal ratio were significantly higher in the 20-min period after acidic infusion than after saline infusion. These results suggest that RMMA episodes including SB were induced by esophageal acidification.