Mechanisms of hemolysis caused by anti-erythrocyte antibodies in the pathological condition of canine babesiosis.

在犬巴贝斯虫病患者的血清中检测到与犬热休克蛋白70(HSP70)反应的抗体。由于巴贝斯虫HSP70与犬HSP70有很高的同源性，抗巴贝斯虫HSP70抗体可能与犬HSP70发生交叉反应。由于犬红细胞表达HSP70，因此犬血清中的抗HSP70抗体可能是抗红细胞膜抗体，但在红细胞膜表面未发现犬HSP70，提示红细胞不是抗HSP70抗体的靶点。

In canine babesiosis, antibodies that reacted with canine heat shock protein 70 (hsp70) were detected in dog sera. Because hsp70 from Babesia parasites showed high homology with canine hsp70, anti-Babesia parasite hsp70 antibody might cross-react with canine hsp70. Since canine hsp70 was expressed in canine erythrocytes, it was possible that anti-hsp70 antibodies in dog sera would be anti-erythrocyte membrane antibodeis ; however, canine hsp70 was not found on the membrane surface of erythrocytes, suggesting that erythrocytes would not be targets of anti-hsp70 antibody.