Chemical approach for elucidating structure and function of a novel glycolipid stimulating the membrane-protein integration.

膜蛋白与脂质膜的整合受到转座子的严格调控，如SecYEG复合物和YidC。近年来，在这一整合过程中发现了一种新的整合刺激因子——糖脂。本研究成功地从大肠杆菌菌株MC4100中提取纯化了该整合因子，并通过核磁共振和质谱分析获得了该整合因子的结构数据，推测了该整合因子的总结构。

Integration of membrane-proteins into lipid membranes is strictly regulated with translocon, such as SecYEG complex and YidC. Recently, a novel integration-stimulating factor, suggested a sort of glycolipid, was found out in this integration process. In this study, we succeeded in extraction and purification of this factor from E. coli strain MC4100 and assumed a total structure of this integration factor by structural data obtained by NMR and MS analyses.