New viewpoint for prevention of life style-related diseases-verification of thrifty phenotype hypothesis

为了弄清出生体重与生活方式相关疾病之间的关系，我们进行了体检。受试者分为两组。我们从她们的产后健康记录簿上得到了出生体重。在243名日本健康高中女生中，发现低出生体重儿与SBP、DBP、TG、胰岛素水平、胰岛素抵抗等代谢综合征的危险因素显著相关，提示在今后的生活中应加强对MS的跟踪研究和饮食教育。在中年组体检中，出生体重与目前BMI的关系呈U型曲线。低出生体重组空腹血糖>100 mg/dl的比例较高。这些数据表明，低出生体重是晚年生活方式相关疾病的高风险。

To clarify the relationships between birth weight and life style related diseases, we examined medical examination. The subjects are two groups. We got birth weights by their maternity health record books. In 243 Japanese healthy high school girls the association of low birth weight could be detected to be significant with such risks of metabolic syndrome as SBP, DBP, TG, insulin level and insulin resistance indicating the importance of follow-up study and food education program for the prevention of MS in the later life. In middle aged group medical examination the relationship between the birth weight and present BMI shows U curve. The ratio of fasting plasma glucose levels over 100mg/dl is high in low birth weight group. These data show that low birth weight is high risk for life style-related diseases in later life.