A comprehensive search for antiangiogenic food factors and molecular biological analysis of their mode of inhibition

近年来，研究表明，实体肿瘤的持续生长需要持续的血液营养和氧气供应，并诱导血管生成，即血管网络的局部扩张，以实现这一目标。研究还表明，抑制这种肿瘤血管生成是一种新的非常有效的癌症治疗策略。作为这一新的癌症治疗策略的应用，对开发可用于预防癌症的抗血管生成食品进行了基础研究。结果表明，各种植物提取物及其有效成分均具有抗血管生成活性，并对其抑制方式进行了比较。

In recent years, it has been shown that for solid tumors to grow continuously they need constant supply of nutrients and oxygen from the blood and they induce angiogenesis, a local expansion of blood vessel network, to achieve that go al. It has also been shown that inhibition of such tumor angiogenesis is a new and very effective strategy for cancer treatment. As an application of this new cancer-treating strategy, a basic research toward developing antiangiogenic foods that can be used to prevent cancer was conducted. As a result, various plant extracts and their active ingredients were shown to possess antiangiogenic activities and their modes of inhibition were compared.