The effect of behavior therapy in obsessive compulsive disorder using both a voxel-based morphometry approach and neuropsychological tasks

在这项研究中，我们研究了存在的区域结构异常的灰质（GM）和白色物质（WM）的强迫症患者在基线使用基于体素的形态学（VBM）的方法在随后的BT的反应者和非反应者。此外，我们用神经心理学的方法检查异常。在12周BT完成前进行T1加权磁共振成像研究。相对于反应者，无反应者在右腹内侧前额叶皮质、右眶额皮质（OFC）、右前扣带回皮质（ACC）中表现出显著较小的GM体积。此外，相对于反应者，无反应者在左侧扣带回束、双侧扣带回束中表现出显著较小的WM体积。两组被试在注意/执行功能上存在差异。这些结果表明，在几个领域，包括OFC，ACC和扣带束的脑结构与缺乏对BT的反应，强迫症患者。使用VBM方法可能有利于理解应答者和无应答者之间的差异。

In this study, we examined the existence of regional structural abnormalities in both the gray matter(GM) and the white matter(WM) of patients with OCD at baseline using a voxel-based morphometry(VBM) approach in responders and non-responders to subsequent BT. In addition, we examined the abnormalities using neuropsychological approach. TheT1-weighted magnetic resonance imaging studies were performed before the completion of 12 weeks of BT. Relative to the responders, the non-responders exhibited significantly smaller GM volumes in the right ventromedial prefrontal cortex, the right orbitofrontal cortex(OFC), the right anterior cingulate cortex(ACC). In addition, relative to the responders, the non-responders exhibited significantly smaller WM volumes in the left cingulate bundle, bilateral cingulate bundles. Two groups exhibited the difference on the part of the attention/executive functions. These results suggest that brain structures in several areas including the OFC, ACC, and cingulate bundles are related to the lack of a response to BT in patients with OCD. The use of a VBM approach may be advantageous to understanding differences between responders and non-responders.