Study on the Regulation Mechanism of Gelation in Biopolymer Gel associated with N-linked Carbohydrate Chain

从目前对纤维蛋白凝胶形成的研究中强烈建议了以下纤维蛋白凝胶形成机制的方案。位于纤维蛋白原分子远端D区的Bβ肽链N-连接的糖链与Bβ链的N-端区域相互作用，抑制B β链的聚集作用，从而形成原纤维，αC结构域介导原纤维的侧向聚集，糖链与Bβ链N端区域的相互作用可能影响其释放。因此，从原纤维的形成/生长到原纤维的侧向聚集的过程受碳水化合物链的调节。

Following scheme of the fibrin gel formation mechanism was strongly suggested from the present study on the fibrin gel formation. Carbohydrate chain N-linked to the Bβ peptide chain that locates in the distal D region of fibrinogen molecule interacts with the N-terminal region of Bβ chain, and inhibits the aggregating action of it succeeding to the protofibril formation.αC domains that mediate the lateral aggregation of protofibrils are bound to the fibrinopeptide B, and the release of them might be affected by the interaction between carbohydrate chain and N-terminal region of Bβ chain. As a result, the switchover from the protofibril formation/growth to the lateral aggregation of protofibrils is regulated by the carbohydrate chain.