Roles of GBF1 in cell migration of neutrophil

众所周知，中性粒细胞迅速迁移到入侵病原体的感染部位，尽管分子机制仍然很大程度上未知。在本研究中，为了解决中性粒细胞迁移的分子机制，我们研究了细胞间运输相关蛋白GBF 1在细胞迁移中的激活机制和作用。我们发现GBF 1被PI（3，4，5）P_3激活，并且GBF 1参与了细胞迁移过程中ARF1和GIT 2的亚细胞定位。

It is known that neutrophils rapidly migrate into the infection sites of invading pathogens, although the molecular mechanism remains largely unknown. In this study, to resolve the molecular mechanism of cell migration in neutrophil, we examined the activation mechanism and roles of GBF1, intercellular trafficking associated protein, in cell migration. We found that GBF1 is activated by PI(3, 4, 5) P_3, and that GBF1 is involved in subcellular localization of ARF1 and GIT2 during cell migration.