Development of Neutralizing Antibodies against Staphylococcal Exfoliative Toxins
Development of Neutralizing Antibodies against Staphylococcal Exfoliative Toxins
批准号:
21580387
负责人:
NISHIFUJI Koji
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
在这个项目中,我们发现对金黄色葡萄球菌剥脱性毒素B(ETB)底物特异性至关重要的氨基酸基序可能位于65-232的氨基酸残基之间。该项目还发现,两种假中间链球菌et选择性地消化犬表皮的细胞-细胞粘附分子-粘粒蛋白1。
英文摘要
In this project, we revealed that amino acid motifs critical for substrate specificity of Staphylococcus aureus exfoliative toxin B(ETB) may be located between amino acid residues of 65-232. This project also revealed that two S. pseudintermedius ETs selectively digest canine desmoglein 1, a cell-cell adhesion molecule in canine epidermis.
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DOI:
10.1111/j.1600-0625.2011.01306.x
发表时间:
2011-09-01
期刊:
EXPERIMENTAL DERMATOLOGY
影响因子:
3.6
作者:
[Yoon, Ji-Seon, Nishifuji, Koji, Iwasaki, Toshiroh]
通讯作者:
Iwasaki, Toshiroh
Development of an enzyme-linked immunosorbent assay for detection of circulating IgG autoantibodies against canine desmoglein 3 in dogs with pemphigus
开发酶联免疫吸附测定法,用于检测患有天疱疮的狗体内针对犬桥粒芯糖蛋白 3 的循环 IgG 自身抗体
DOI:
--
发表时间:
2009
期刊:
Vet Dermatol 20
影响因子:
--
作者:
[Iyori K, et al., 杉崎修・小林正人・小堤友香梨・田中優・守谷友加里・石井典子・山田理・礒谷真由・伊藤慶太・盆子原誠・小野憲一郎・鷲巣月美, Kobayashi T, Nishifuji K]
通讯作者:
Nishifuji K
DOI:
10.1111/j.1574-6968.2010.02113.x
发表时间:
2010-11-01
期刊:
FEMS MICROBIOLOGY LETTERS
影响因子:
2.1
作者:
[Iyori, Keita, Hisatsune, Junzo, Nishifuji, Koji]
通讯作者:
Nishifuji, Koji
DOI:
10.1292/jvms.10-0172
发表时间:
2010-12-01
期刊:
JOURNAL OF VETERINARY MEDICAL SCIENCE
影响因子:
1.2
作者:
[Kawakami, Tetsuji, Shibata, Sanae, Fukata, Tsuneo]
通讯作者:
Fukata, Tsuneo
Removal of amino-terminal extracellular domains of desmoglein 1 by staphylococcal exfoliative toxin is sufficient to initiate epidermal blister formation
通过葡萄球菌剥脱性毒素去除桥粒芯糖蛋白 1 的氨基末端胞外结构域足以引发表皮水疱形成
DOI:
--
发表时间:
2010
期刊:
J Dermatol Sci
影响因子:
4.6
作者:
[Jiageng Chen, Shoichi Hirose, Hidenori Kuwakado, and Atsuko Miyaji, Nishifuji K]
通讯作者:
Nishifuji K
共 8 条
Investigation of host-bacterial interactions in staphylococcal cutaneous infection and development of its prevention strategies
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批准号:17H03922
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.23万
-
财政年份:2017
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负责人:NISHIFUJI Koji
-
依托单位:
Investigation of unknown transdifferentiation mechanisms of cutaneous epithelial tumor and related genes
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批准号:25660237
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.58万
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财政年份:2013
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负责人:NISHIFUJI Koji
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依托单位:
海外基金