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Development of Neutralizing Antibodies against Staphylococcal Exfoliative Toxins

Development of Neutralizing Antibodies against Staphylococcal Exfoliative Toxins
抗葡萄球菌剥脱性毒素中和抗体的研制
批准号:
21580387
负责人:
NISHIFUJI Koji
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

项目摘要

项目成果

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中文摘要
翻译
在这个项目中,我们发现对金黄色葡萄球菌剥脱性毒素B(ETB)底物特异性至关重要的氨基酸基序可能位于65-232的氨基酸残基之间。该项目还发现,两种假中间链球菌et选择性地消化犬表皮的细胞-细胞粘附分子-粘粒蛋白1。
英文摘要
In this project, we revealed that amino acid motifs critical for substrate specificity of Staphylococcus aureus exfoliative toxin B(ETB) may be located between amino acid residues of 65-232. This project also revealed that two S. pseudintermedius ETs selectively digest canine desmoglein 1, a cell-cell adhesion molecule in canine epidermis.
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会议论文
DOI: 10.1111/j.1600-0625.2011.01306.x
发表时间: 2011-09-01
期刊: EXPERIMENTAL DERMATOLOGY
影响因子: 3.6
作者: [Yoon, Ji-Seon, Nishifuji, Koji, Iwasaki, Toshiroh]
通讯作者: Iwasaki, Toshiroh
Development of an enzyme-linked immunosorbent assay for detection of circulating IgG autoantibodies against canine desmoglein 3 in dogs with pemphigus
开发酶联免疫吸附测定法,用于检测患有天疱疮的狗体内针对犬桥粒芯糖蛋白 3 的循环 IgG 自身抗体
DOI: --
发表时间: 2009
期刊: Vet Dermatol 20
影响因子: --
作者: [Iyori K, et al., 杉崎修・小林正人・小堤友香梨・田中優・守谷友加里・石井典子・山田理・礒谷真由・伊藤慶太・盆子原誠・小野憲一郎・鷲巣月美, Kobayashi T, Nishifuji K]
通讯作者: Nishifuji K
DOI: 10.1111/j.1574-6968.2010.02113.x
发表时间: 2010-11-01
期刊: FEMS MICROBIOLOGY LETTERS
影响因子: 2.1
作者: [Iyori, Keita, Hisatsune, Junzo, Nishifuji, Koji]
通讯作者: Nishifuji, Koji
DOI: 10.1292/jvms.10-0172
发表时间: 2010-12-01
期刊: JOURNAL OF VETERINARY MEDICAL SCIENCE
影响因子: 1.2
作者: [Kawakami, Tetsuji, Shibata, Sanae, Fukata, Tsuneo]
通讯作者: Fukata, Tsuneo
共 8 条
    Investigation of host-bacterial interactions in staphylococcal cutaneous infection and development of its prevention strategies
    Investigation of unknown transdifferentiation mechanisms of cutaneous epithelial tumor and related genes
    海外基金