Epidemiologic and experimental study to clarify involvement of heavy metals in Parkinson's disease

从中国血液和尿液中金属和维生素浓度的病例对照研究结果来看，铁和铜的过量摄入、锰的积累、摄入维生素E/铜的不平衡以及体内缺锌导致的维生素B12减少可能与帕金森病的病因有关。我们对小鼠CD1脑纹状体神经元细胞的实验研究表明，锰可能导致烟酰胺n -甲基转移酶活性增加，从而增加脑内1-甲基烟酰胺水平，导致神经元死亡。

From the results of the case-control study in China comparing concentrations of metals and vitamins in blood and urine, excessive intake of iron and copper, accumulation of manganese, vitamin E/copper imbalance in intake, and vitamin B12 decrease by zinc deficiency in the body might be involved in the etiology of Parkinson's disease.Our experimental study using Mouse CD1 brain striatum neuronal cells suggests the possibility that manganese causes increased nicotinamide N-methyltransferase activity, thereby increasing 1-methylnicotinamide levels in the brain and bringing about neuron death.