Exploring the roles of sphingosine 1-phosphate(S1P), a lipid mediator, in ischemic heart

我们进行了实验研究，以探讨S1P及其相关分子在缺血性心脏病中的作用。已证实，富含鞘磷脂的外周细胞膜微区小窝及其结构成分小窝蛋白-1在介导S1P信号转导中起关键作用。我们确定细胞因子转化生长因子β-1通过抑制小窝蛋白-1的表达促进血管内皮细胞的S1P信号转导。我们还发现，类固醇激素能够上调小窝蛋白-1，下调血管内皮生长因子受体信号通路。

We performed experimental research to explore the roles of S1P and related molecules in ischemic heart diseases. It has been established that sphingolipid-enriched micro-compartments of peripheral plasma membrane termed caveolae and their structural component protein caveolin-1 play key roles in mediating S1P signaling. We determined that a cytokine TGFβ1 promotes S1P signaling in cultured vascular endothelial cells by attenuating caveolin-1 expression. We also discovered that steroid hormones are capable of up-regulating caveolin-1 to down-regulated VEGF receptor signaling pathways.