Anti-fibrotic effects of klotho through the inhibition of Wnt signaling

随着年龄的增长，肾脏的纤维化程度增加，并逐渐发展为慢性肾功能衰竭。肾脏分泌的Klotho蛋白通过抑制促进纤维化的Wnt信号而减轻纤维化，进展为肾功能障碍。随着年龄的增长，器官纤维化的进展与肾脏一样，并导致器官功能的衰退。但Klotho不仅可以抑制肾脏的纤维化，还可以抑制其他器官的纤维化，可能有助于延缓衰老。保持肾功能正常可能有助于延缓衰老。

The kidney increases fibrotic changes with aging and gradually progresses to chronic renal failure. The Klotho protein secreted by kidney attenuates fibrosis, progress to renal dysfunction by inhibiting Wnt signal promoting fibrosis. Organ fibrotic changes progresses as well as kidney with aging and leads to organ functional decline with aging. But Klotho may restrain fibrosis of not only the kidney but also the other organs and may work for anti-aging. To keep the renal function normally may lead to the prevention of the aging.