Analysis of autoimmune response to claudin-family proteins in demyelinating disease.

为了阐明自身免疫应答CLDND1在多发性硬化症（MS）中的作用，我们检测了MS患者血清中抗CLDND1自身抗体。我们发现抗水通道蛋白-4抗体阳性的MS患者的抗cldnd1血清阳性显著增加（41）。2%)，而对照组（3%）。2%)。CLDND1在中枢神经系统髓磷脂、神经元和内皮细胞中表达。我们的研究结果提示，抗aqp4抗体阳性MS中CLDND1的自身免疫反应与脱髓鞘和血脑屏障的转移有关。

To clarify the role of autoimmune response to claudin domain containing 1(CLDND1) in multiple sclerosis(MS), we measured serum anti-CLDND1 autoantibody in MS patients. We found a significant increase in anti-CLDND1 seropositivity in anti-aquaporin-4 antibody positive MS patients(41. 2%) compared with controls(3. 2%). CLDND1 was expressed in the myelin, neuron and endothelial cell in the central nervous system. The result of our study suggest that the autoimmune response to CLDND1 is related with demyelination and distraction of BBB in anti-AQP4 antibody positive MS.