Elucidation of new mechanisms of RSV infection by clinical isolate analysis using a mouse model

无论在临床研究还是基础研究中都没有关于RSV感染后Th2诱导的结论。通过比较Th2衍生RSV株（RSV- line 19）、RSV- a2株和RSV- long株，发现F基因有5个氨基酸改变的基因突变。我们分析了49株RSV临床分离株的F基因，并分析了先前报道的基因突变。在5株分离株中发现了先前报道的基因突变，但突变为1 ~ 2处。

There has not been conclusion about Th2 induction after RSV infection both in clinical researches and basic researches. Five gene mutations with amino acids alteration are reported in F gene by comparison among Th2 derivation RSV strain(RSV-Line 19), RSV-A2 strain and RSV-Long strain. We analyzed an F gene about 49 RSV clinical isolates and analyzed a gene mutation reported previously. Gene mutation of previous report was found in five isolates, but mutation was 1 or two places.