The investigation and reconstruction of bipolar spectrum and its clinical application to depression

双相频谱是介于双相I障碍和单相抑郁之间的一个概念。虽然双相I和双相II是《精神疾病诊断和统计手册》第四版(DSM-IV)官方命名的一部分，但双相频谱的这种概念在本手册中并不存在。为了澄清这种相互矛盾的情况，我们对健康志愿者和情绪障碍患者进行了研究。我们的结果表明，气质可能在双相和单相抑郁之间划出界限，气质可能由几个生物因素组成，如照度、中枢5-羟色胺能功能和睡眠模式。虽然双相频谱的概念强调连续性，但可能存在一个拐点，使药物反应发生变化，即双相频谱对情绪稳定剂的反应和单相抑郁对抗抑郁药物的反应。

Bipolar spectrum is a concept which bridges between bipolar I disorder and unipolar depression. Although bipolar I and bipolar II are part of the official nomenclature of Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition(DSM-IV), such concept of bipolar spectrum is not represented in this manual. To clarify this conflicting situation, we performed studies using healthy volunteers and patients with mood disorders. Our results suggest that temperaments may draw a boundary between bipolar spectrum and unipolar depression and temperaments may consist of several biological factors such as illuminance, central serotonergic function, and sleep pattern. Although the concept of bipolar spectrum emphasizes continuity, there may be an inflexion point which makes changes in drug responses, which are the response of bipolar spectrum to mood stabilizers and that of unipolar depression to antidepressants.