3D analysis of regional hepatic blood flow by means of hepatic imaging using monochromatic synchrotron radiation

采用单色同步辐射肝血流成像技术对局部肝血流进行三维分析。我们的研究结果表明，微型ct可以评估小动脉和门静脉之间的微吻合以及新生血管的程度。这一事实可能有助于阐明在对比增强动态CT或MRI中观察到的早期增强肝假性脓肿的原因。Gd-EOB-DTPA作为肝细胞特异性造影剂的肝内分布也通过正常小鼠和NASH模型小鼠进行评估。在正常小鼠中，肝细胞主要摄取Gd-EOB-DTPA。在NASH模型小鼠中，Gd-EOB-DTPA的摄取随着肝纤维化的进展逐渐减少，提示肝细胞功能与肝血流动态变化之间的关系。在肝内Gd沉积方面，肾功能障碍模型大鼠Gd沉积最少。然而，肝肾功能障碍模型大鼠的Gd沉积增加，表明肝功能恶化的风险增加。

3D analysis of regional hepatic blood flow was performed by means of hepatic flow imaging using monochromatic synchrotron radiation. Our results showed that micro-CT enables the evaluation of microanastomosis between small arteries and portal veins as well as the degree of neovascularization. This fact may help elucidate the cause of early enhancing hepatic pseudolesions observed in contrast-enhanced dynamic CT or MRI. Intrahepatic distribution of Gd-EOB-DTPA as a hepatocyte-specific contrast agent was also assessed by using normal and NASH model mouse. In normal mouse, predominant uptake of Gd-EOB-DTPA in the hepatocyte was observed. In NASH model mouse, uptake of Gd-EOB-DTPA gradually decreased, according to the progression of hepatic fibrosis, suggesting the relationship between hepatocyte function and dynamic changes of hepatic blood flow. Regarding the Gd deposition in the liver, Gd deposition in renal dysfunction model rat was minimal. However, Gd deposition was increased in hepatorenal dysfunction model rat, indicating the increased risk of deterioration of liver function.