Development of novel production method of high purity lutetium-177 for advanced cancer therapy

镥-177被认为在放射性核素治疗中具有应用潜力，因为它释放出适合穿透小肿瘤的b粒子。此外，利用^<177>Lu可以实现生物分布的实时成像，因为^<177>Lu发射的g射线的能量特别适合单光子发射计算机断层成像。在使用标记单克隆抗体的放射免疫治疗领域，为了提高治疗效果，需要在^<176>Yb(n, g) ^<177>Yb→^<177>Lu过程中产生无载体添加的^<177>Lu。在这种生产中，需要从Yb目标中分离出^<177>Lu。因此，本文对亚氨基二乙酸螯合树脂分离Lu和Yb进行了基础研究。结果表明，以0.013 M HNO_3为洗脱液，柱尺寸为4.6 mmφx450 mm时，Lu与Yb的分离效果最好。

Lutetium-177 is considered to have potential for application in radionuclide therapy, because it emits b-particles suitable to penetrate small tumors. In addition, real time imaging of biodistribution can be done by using the ^<177>Lu, because the energy of g-rays emitted from ^<177>Lu is particularly suitable for imaging by single photon emission computed tomography. In the field of radioimmunotherapy using labeled monoclonal antibodies, to enhance the effect of therapy, no-carrier-added ^<177>Lu produced in the ^<176>Yb(n, g) ^<177>Yb → ^<177>Lu process are desired. In this production, separation of ^<177>Lu from Yb target is required. Therefore, in the present paper, basic study of separation between Lu and Yb by using iminodiacetic acid chelating resin is investigated. It was found that the best separation between Lu and Yb was achieved by using 0.013 M HNO_3 for the eluent and the column of 4.6 mmφｘ450 mm size.