Biodegradable stent of external wrapping with autologous vein grafts prevents graft stenosis at long term in a canine model

在冠状动脉旁路移植术中，自体移植静脉长期狭窄和闭塞一直是一个重要的临床问题。为了防止移植物狭窄，降低壁应力是非常重要的。因此，我们在犬静脉移植物模型上验证了生物可降解支架外包裹可以长期预防移植物狭窄的假设。在比格犬身上进行股动脉移植。分为3组：不植入外支架组(对照组)、植入生物可降解支架(P(LA/CL))组和非生物降解支架(PP组)组。P(LA/CL)组各时间点移植静脉管径接近，通畅率明显高于其他组。因此，自体静脉外包裹生物可降解支架在犬模型中可以长期预防移植物狭窄。

In the CABG surgery, autologous vein graft stenosis and occlusion at long term has been a significant clinical issue. It was said that reduction of the wall stress was very important in order to prevent graft stenosis. So, we tested the hypothesis that biodegradable stent wrapped externally can prevent graft stenosis at long term in a canine vein graft model. Femoral artery graft interposition was performed in beagles. They were divided into 3 groups : graft interposition without external stent(control); with biodegradable stent (poly L-lactic acid and epsilon-caprolactone copolymer(P(LA/CL)); with non-biodegradable stent(polypropylene). At P(LA/CL)group, diameters of vein graft was the similar value at any point, patency was significantly improved compared with the other groups. Therefore biodegradable stent of external wrapping with autologous vein grafts can prevent graft stenosis at long term in a canine model.