Overcome of resistance to therapy of maliganant gliomas by induction of autophagy

恶性胶质瘤细胞对化疗药物和放疗具有耐药性。对细胞凋亡的抵抗是这种治疗抵抗的主要机制。细胞程序性死亡的第二种机制，自噬是目前恶性胶质瘤细胞重要的细胞死亡过程。探讨了药物诱导恶性胶质瘤细胞自噬的可能性。抗凋亡药物和自噬诱导药物诱导胶质瘤细胞自噬。该策略可能是治疗恶性胶质瘤的一种新方法。

Malignant glioma cells are resisitant to chemothereutic agents and irradiation. The resistance to apoptosis is the main mechanism of this resistance to therapy. The second programmed cell death mechanism, autophagy is now important cell death process of malignant glioma cells. The authors investigated possibility of autophagy induction of malignant glioma cells by pharmaceutical methods. Antiapoptotic drugs and autophagy inducing drugs induced glioma cell autophagy. This strategy may be a novel therapeutic method of maliganat gliomas.