Molecular basis clarification for pain and stress reaction in injury and arthritis of transgenic animals.

本研究的目的是探讨外周组织对伤害性应激的接受与中枢神经系统对应激的反应之间的关系。取得了如下重要成果。(1)福尔马林实验是急性伤害性应激模型，在下丘脑引起快速的神经内分泌反应。(2)在伤害性应激后，脊髓背角和下丘脑室旁核中观察到了被广泛用于指示神经元激活的即刻早期基因表达。(3)受体激活的Ca2+通道，如瞬时受体电位，参与外周组织中伤害性应激的处理。

The purpose of the study was to examine the relationship between acceptance of nociceptive stress at peripheral tissue and response against the stress at the central nervous system. We obtained significant results as follow. (1) Formalin test which was acute nociceptive stress model induced rapid neuroendocrine response in the hypothalamus. (2) Immediate early gene expression which was widely used for indication of activated of neurons was observed in the dorsal horn of the spinal cord and the hypothalamic paraventricular nucleus after nociceptive stress. (3) Receptor-activated Ca2+-channels such as transient receptor potential involved in processing nociceptive stress in the peripheral tissue.